Difference between revisions of "Ontology for Parasite Life Cycle"

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**[[Entity|entity]]
 
**[[Entity|entity]]
 
***[[Continuant|continuant]]
 
***[[Continuant|continuant]]
 +
****[[Dependent_Contininuant|dependent_continuant]]
 +
*****[[Specifically_Dependent_Continuant|specifically_dependent_continuant]]
 +
******[[Realizable_Entity|realizable_entity]]
 +
*******[[Role|role]]
 +
********[[Parasite_Role|parasite_role]]
 +
*********[[Human_Parasite_Role|human_parasite_role]]
 +
********[[Infectious_Agent_Vector_Role|infection_agent_vector_role]]
 +
*********[[Biological_Vector_of_Infections_Agent_Role|biological_vector_of_infectious_agent_role]]
 +
********[[Host_Role|host_role]]
 +
*********[[Definitive_Host_Role|definitie_host_role]]
 +
*********[[Intermediate_Host_Role|intermediate_host_role]]
 
****[[Independent_Continuant|independent_continuant]]
 
****[[Independent_Continuant|independent_continuant]]
−
*****[[Organism|Organism]]
+
*****[[Material_Entity|material_entity]]
−
******[[Mollusca|mollusca]]
+
******[[Organism|Organism]]
−
*******[[Bulinus|bulinus]]
+
*******[[Mollusca|mollusca]]
−
*******[[Oncomelania|oncomelania]]
+
********[[Bulinus|bulinus]]
−
*******[[Biomphalaria|biomphalaria]]
+
********[[Oncomelania|oncomelania]]
−
******[[Insect|insect]]
+
********[[Biomphalaria|biomphalaria]]
−
*******[[Phlebotominae|Phlebotominae]]
+
*******[[Insect|insect]]
−
*******[[Triatominae|triatominae]]
+
********[[Phlebotominae|Phlebotominae]]
−
*******[[Anopheles|anopheles]]
+
********[[Triatominae|triatominae]]
−
*******[[Glossina|glossina]]
+
********[[Anopheles|anopheles]]
−
******[[Parasite_Organism|parasite_organism]]
+
********[[Glossina|glossina]]
−
*******[[Leishmania|leishmania]]
+
*******[[Parasite_Organism|parasite_organism]]
−
********[[Leishmania_major|leishmania_major]]
+
********[[Leishmania|leishmania]]
−
*********[[Leishmania_major_Amastigote|leishmania_major_amastigote]]
+
*********[[Leishmania_major|leishmania_major]]
−
*********[[Leishmania_major_Promastigote|leishmania_major_promastigote]]
+
**********[[Leishmania_major_Amastigote|leishmania_major_amastigote]]
−
**********[[Leishmania_major_Metacyclic_Promastigote|leishmania_major_metacyclic_promastigote]]
+
**********[[Leishmania_major_Promastigote|leishmania_major_promastigote]]
−
**********[[Leishmania_major_Procyclic_Promastigote|leishmania_major_procyclic_promastigote]]
+
***********[[Leishmania_major_Metacyclic_Promastigote|leishmania_major_metacyclic_promastigote]]
−
*******[[Trypanosoma|trypanosoma]]
+
***********[[Leishmania_major_Procyclic_Promastigote|leishmania_major_procyclic_promastigote]]
−
********[[Trypanosoma_brucei|trypanosoma_brucei]]
+
********[[Trypanosoma|trypanosoma]]
−
*********[[Trypanosoma_brucei_Epimastigote|trypanosoma_brucei_epimastigote]]
+
*********[[Trypanosoma_brucei|trypanosoma_brucei]]
−
*********[[Trypanosoma_brucei_Metacyclic_Trypomastigote|trypanosoma_brucei_metacyclic_trypomastigote]]
+
**********[[Trypanosoma_brucei_Epimastigote|trypanosoma_brucei_epimastigote]]
−
*********[[Trypanosoma_brucei_Procyclic_Trypomastigote|trypanosoma_brucei_procyclic_trypomastigote]]
+
**********[[Trypanosoma_brucei_Trypomastigote|trypanosoma_brucei_trypomastigote]]
−
*********[[Trypanosoma_brucei_Trypomastigote|trypanosoma_brucei_trypomastigote]]
+
***********[[Trypanosoma_brucei_Metacyclic_Trypomastigote|trypanosoma_brucei_metacyclic_trypomastigote]]
−
********[[Trypanosoma_cruzi|trypanosoma_cruzi]]
+
***********[[Trypanosoma_brucei_Procyclic_Trypomastigote|trypanosoma_brucei_procyclic_trypomastigote]]
−
*********[[Trypanosoma_cruzi_Amastigote|trypanosoma_cruzi_amastigote]]
+
*********[[Trypanosoma_cruzi|trypanosoma_cruzi]]
−
*********[[Trypanosoma_cruzi_Epimastigote|trypanosoma_cruzi_epimastigote]]
+
**********[[Trypanosoma_cruzi_Amastigote|trypanosoma_cruzi_amastigote]]
−
*********[[Trypanosoma_cruzi_Metacyclic_Trypomastigote|trypanosoma_cruzi_metacyclic_trypomastigote]]
+
**********[[Trypanosoma_cruzi_Epimastigote|trypanosoma_cruzi_epimastigote]]
−
*********[[Trypanosoma_cruzi_Trypomastigote|trypanosoma_cruzi_trypomastigote]]
+
**********[[Trypanosoma_cruzi_Trypomastigote|trypanosoma_cruzi_trypomastigote]]
−
*******[[Plasmodium|plasmodium]]
+
***********[[Trypanosoma_cruzi_Metacyclic_Trypomastigote|trypanosoma_cruzi_metacyclic_trypomastigote]]
−
********[[Plasmodium_falciparum|plasmodium_falciparum]]
+
********[[Plasmodium|plasmodium]]
−
*********[[Plasmodium_falciparum_Erythrocytic_Schizont|plasmodium_falciparum_erythrocytic_schizont]]
+
*********[[Plasmodium_falciparum|plasmodium_falciparum]]
−
*********[[Plasmodium_falciparum_Hepatic_Schizont|plasmodium_falciparum_hepatic_schizont]]
+
**********[[Plasmodium_falciparum_Erythrocytic_Schizont|plasmodium_falciparum_erythrocytic_schizont]]
−
*********[[Plasmodium_falciparum_Macrogamete|plasmodium_falciparum_macrogamete]]
+
**********[[Plasmodium_falciparum_Hepatic_Schizont|plasmodium_falciparum_hepatic_schizont]]
−
*********[[Plasmodium_falciparum_Macrogametocyte|plasmodium_falciparum_macrogametocyte]]
+
**********[[Plasmodium_falciparum_Macrogamete|plasmodium_falciparum_macrogamete]]
−
*********[[Plasmodium_falciparum_Merozoite|plasmodium_falciparum_merozoite]]
+
**********[[Plasmodium_falciparum_Macrogametocyte|plasmodium_falciparum_macrogametocyte]]
−
*********[[Plasmodium_falciparum_Microgamete|plasmodium_falciparum_microgamete]]
+
**********[[Plasmodium_falciparum_Merozoite|plasmodium_falciparum_merozoite]]
−
*********[[Plasmodium_falciparum_Microgametocyte|plasmodium_falciparum_microgametocyte]]
+
**********[[Plasmodium_falciparum_Microgamete|plasmodium_falciparum_microgamete]]
−
**********[[Plasmodium_falciparum_Exflagellated_Microgametocyte|plasmodium_falciparum_exflagellated_microgametocyte]]
+
**********[[Plasmodium_falciparum_Microgametocyte|plasmodium_falciparum_microgametocyte]]
−
*********[[Plasmodium_falciparum_Oocyst|plasmodium_falciparum_oocyst]]
+
***********[[Plasmodium_falciparum_Exflagellated_Microgametocyte|plasmodium_falciparum_exflagellated_microgametocyte]]
−
*********[[Plasmodium_falciparum_Ookinete|plasmodium_falciparum_ookinete]]
+
**********[[Plasmodium_falciparum_Oocyst|plasmodium_falciparum_oocyst]]
−
*********[[Plasmodium_falciparum_Ring_Trophozoite|plasmodium_falciparum_ring_trophozoite]]
+
**********[[Plasmodium_falciparum_Ookinete|plasmodium_falciparum_ookinete]]
−
*********[[Plasmodium_falciparum_Sporozoite|plasmodium_falciparum_sporozoite]]
+
**********[[Plasmodium_falciparum_Ring_Trophozoite|plasmodium_falciparum_ring_trophozoite]]
−
*********[[Plasmodium_falciparum_Trophozoite|plasmodium_falciparum_trophozoite]]
+
**********[[Plasmodium_falciparum_Sporozoite|plasmodium_falciparum_sporozoite]]
−
*********[[Plasmodium_falciparum_Zygote|plasmodium_falciparum_zygote]]
+
**********[[Plasmodium_falciparum_Trophozoite|plasmodium_falciparum_trophozoite]]
−
*******[[Schistosoma|schistosoma]]
+
**********[[Plasmodium_falciparum_Zygote|plasmodium_falciparum_zygote]]
−
********[[Schistosoma_japonicum|schistosoma_japonicum]]
+
********[[Schistosoma|schistosoma]]
−
********[[Schistosoma_mansoni|schistosoma_mansoni]]
+
*********[[Schistosoma_japonicum|schistosoma_japonicum]]
−
********[[Schistosoma_haematobium|schistosoma_haematobium]]
+
**********[[Schistosoma_Japonicum_Cercaria|schistosoma_japonicum_cercaria]]
−
******[[Vertebrate|vertebrate]]
+
**********[[Schistosoma_Japonicum_Egg|schistosoma_japonicum_egg]]
−
*******[[Mammal|mammal]]
+
**********[[Schistosoma_Japonicum_Miracidium|schistosoma_japonicum_miracidium]]
−
********[[Mus_musculus|mus_musculus]]
+
**********[[Schistosoma_Japonicum_Schistosomulum|schistosoma_japonicum_schistosomulum]]
−
********[[Homo_sapiens|homo_sapiens]]
+
***********[[Schistosoma_24_Hour_Japonicum_Schistosomulum|schistosoma_24_hour_japonicum_schistosomulum]]
−
********[[Canis_familiaris|canis_familiaris]]
+
***********[[Schistosoma_3_Day_Japonicum_Schistosomulum|schistosoma_3_day_japonicum_schistosomulum]]
−
*****[[Anatomical_Structure|anatomical_structure]]
+
***********[[Schistosoma_3_Hour_Japonicum_Schistosomulum|schistosoma_3_hour_japonicum_schistosomulum]]
−
******[[Proboscis|proboscis]]
+
***********[[Schistosoma_6_Day_Japonicum_Schistosomulum|schistosoma_6_day_japonicum_schistosomulum]]
−
*******[[Phlebotominae_proboscis|Phlebotominae_proboscis]]
+
**********[[Schistosoma_Japonicum_Sporocyst|schistosoma_japonicum_sporocyst]]
−
******[[Cell|cell]]
+
***********[[Schistosoma_Japonicum_Daughter_Sporocyst|schistosoma_japonicum_daughter_sporocyst]]
−
*******[[Hepatocyte|hepatocyte]]
+
***********[[Schistosoma_Japonicum_Mother_Sporocyst|schistosoma_japonicum_mother_sporocyst]]
−
********[[Human_Hepatocyte|human_hepatocyte]]
+
**********[[Schistosoma_Japonicum_Worm|schistosoma_japonicum_worm]]
−
*******[[Erythrocyte|erythrocyte]]
+
***********[[Schistosoma_Japonicum_3_Week_Worm|schistosoma_japonicum_3_week_worm]]
−
********[[Human_Erythrocyte|human_erythrocyte]]
+
***********[[Schistosoma_Japonicum_7_Week_Worm|schistosoma_japonicum_7_week_worm]]
−
*******[[Macrophage|macrophage]]
+
*********[[Schistosoma_mansoni|schistosoma_mansoni]]
−
********[[Human_Macrophage|human_macrophage]]
+
**********[[Schistosoma_Mansoni_Sporocyst|schistosoma_mansoni_sporocyst]]
−
******[[Blood|blood]]
+
***********[[Schistosoma_Mansoni_Daughter_Sporocyst|schistosoma_mansoni_daughter_sporocyst]]
−
*******[[Human_Blood|human_blood]]
+
***********[[Schistosoma_Mansoni_Mother_Sporocyst|schistosoma_mansoni_mother_sporocyst]]
−
******[[Salivary_Gland|salivary_gland]]
+
**********[[Schostosoma_Mansoni_Cercaria|schostosoma_mansoni_cercaria]]
−
*******[[Anophele_Salivary_Gland|anopheles_salivary_gland]]
+
**********[[Schostosoma_Mansoni_Egg|schostosoma_mansoni_egg]]
−
*******[[Glossina_Salivary_Gland|glossina_salivary_gland]]
+
**********[[Schostosoma_Mansoni_Miracidium|schostosoma_mansoni_miracidium]]
−
******[[Midgut|midgut]]
+
**********[[Schostosoma_Mansoni_Schistosomulum|schostosoma_mansoni_schistosomulum]]
−
*******[[Anopheles_Midgut|anopheles_midgut]]
+
***********[[Schostosoma_Mansoni_24_Hour_Schistosomulum|schostosoma_mansoni_24_hour_schistosomulum]]
−
*******[[Glossina_Midgut|glossina|midgut]]
+
***********[[Schostosoma_Mansoni_3_Day_Schistosomulum|schostosoma_mansoni_3_day_schistosomulum]]
−
*******[[Triatominae_Midgut|triatominae_midgut]]
+
***********[[Schostosoma_Mansoni_3_Hour_Schistosomulum|schostosoma_mansoni_3_hour_schistosomulum]]
−
*******[[Phlebotominae_Midgut|Phlebotominae_midgut]]
+
***********[[Schostosoma_Mansoni_6_Day_Schistosomulum|schostosoma_mansoni_6_day_schistosomulum]]
−
******[[Hindgut|hindgut]]
+
**********[[Schostosoma_Mansoni_Worm|schostosoma_mansoni_worm]]
−
*******[[Triatominae_Hindgut|triatominae_hindgut]]
+
***********[[Schostosoma_Mansoni_3_Week_Worm|schostosoma_mansoni_3_week_worm]]
−
******[[Cerebrospinal_Fluid|cerebrospinal_fluid]]
+
***********[[Schostosoma_Mansoni_7_Week_Worm|schostosoma_mansoni_7_week_worm]]
−
*******[[Human_Cerebrospinal_Fluid|human_cerebrospinal_fluid]]
+
*********[[Schistosoma_haematobium|schistosoma_haematobium]]
 +
**********[[Schistosoma_Haematobium_Cercaria|schistosoma_haematobium_cercarcia]]
 +
**********[[Schistosoma_Haematobium_Egg|schistosoma_haematobium_egg]]
 +
**********[[Schistosoma_Haematobium_Miracidium|schistosoma_haematobium_miracidium]]
 +
**********[[Schistosoma_Haematobium_Schistosomulum|schistosoma_haematobium_schistosomulum]]
 +
***********[[Schistosoma_Haematobium_24_Hour_Schistosomulum|schistosoma_haematobium_24_hour_schistosomulum]]
 +
***********[[Schistosoma_Haematobium_3_Day_Schistosomulum|schistosoma_haematobium_3_day_schistosomulum]]
 +
***********[[Schistosoma_Haematobium_3_Hour_Schistosomulum|schistosoma_haematobium_3_hour_schistosomulum]]
 +
***********[[Schistosoma_Haematobium_6_Day_Schistosomulum|schistosoma_haematobium_6_day_schistosomulum]]
 +
**********[[Schistosoma_Haematobium_Sporocyst|schistosoma_haematobium_sporocyst]]
 +
***********[[Schistosoma_Haematobium_Daughter_Sporocyst|schistosoma_haematobium_daughter_sporocyst]]
 +
***********[[Schistosoma_Haematobium_Mother_Sporocyst|schistosoma_haematobium_mother_sporocyst]]
 +
**********[[Schistosoma_Haematobium_Worm|schistosoma_haematobium_worm]]
 +
***********[[Schistosoma_Haematobium_3_Week_Worm|schistosoma_haematobium_3_week_worm]]
 +
***********[[Schistosoma_Haematobium_7_Week_Worm|schistosoma_haematobium_7_week_worm]]
 +
*******[[Vertebrate|vertebrate]]
 +
********[[Mammal|mammal]]
 +
*********[[Mus_musculus|mus_musculus]]
 +
*********[[Homo_sapiens|homo_sapiens]]
 +
*********[[Canis_familiaris|canis_familiaris]]
 +
******[[Anatomical_Structure|anatomical_structure]]
 +
*******[[Hepatopancreas|hepatopancreas]]
 +
********[[Biompharlaria_Hepatopancreas|biomphalaria_hepatopancreas]]
 +
********[[Bulinus_Hepatopancreas|bulinus_hepatopancreas]]
 +
********[[Oncomelania_Hepatopancreas|oncomelania_hepatopancreas]]
 +
*******[[Proboscis|proboscis]]
 +
********[[Phlebotominae_proboscis|Phlebotominae_proboscis]]
 +
*******[[Cell|cell]]
 +
********[[Hepatocyte|hepatocyte]]
 +
*********[[Human_Hepatocyte|human_hepatocyte]]
 +
********[[Erythrocyte|erythrocyte]]
 +
*********[[Human_Erythrocyte|human_erythrocyte]]
 +
********[[Macrophage|macrophage]]
 +
*********[[Human_Macrophage|human_macrophage]]
 +
*******[[Urinary_Bladder|urinary_bladder]]
 +
********[[Human_Bladder|human_bladder]]
 +
*******[[Mesenteric_Vein|mesenteric_vein]]
 +
********[[Human_Mesenteric_Vein|human_mesenteric_vein]]
 +
*******[[Ureter|ureter]]
 +
********[[Human_Ureter|human_ureter]]
 +
*******[[Intestine|intestine]]
 +
********[[Human_Intestine|human_intestine]]
 +
*******[[Blood|blood]]
 +
********[[Human_Blood|human_blood]]
 +
*******[[Salivary_Gland|salivary_gland]]
 +
********[[Anophele_Salivary_Gland|anopheles_salivary_gland]]
 +
********[[Glossina_Salivary_Gland|glossina_salivary_gland]]
 +
*******[[Midgut|midgut]]
 +
********[[Anopheles_Midgut|anopheles_midgut]]
 +
********[[Glossina_Midgut|glossina|midgut]]
 +
********[[Triatominae_Midgut|triatominae_midgut]]
 +
********[[Phlebotominae_Midgut|Phlebotominae_midgut]]
 +
*******[[Hindgut|hindgut]]
 +
********[[Triatominae_Hindgut|triatominae_hindgut]]
 +
*******[[Cerebrospinal_Fluid|cerebrospinal_fluid]]
 +
********[[Human_Cerebrospinal_Fluid|human_cerebrospinal_fluid]]
 +
*******[[Lung|lung]]
 +
********[[Human_Lung|human_lung]]
 +
*******[[Skin_Of_Body|skin_of_body]]
 +
********[[Human_Skin|human_skin]]
 +
*******[[Liver|liver]]
 +
********[[Human_Liver|human_liver]]
 
***[[Occurrent|occurrent]]
 
***[[Occurrent|occurrent]]
 
****[[Processual_Entity|proccessual_entity]]
 
****[[Processual_Entity|proccessual_entity]]
−
*****[[Amastigote_Stage|amastigote_stage]]
+
*****[[Lifecycle_Stage|lifecycle_stage]]
−
*****[[Epimastigote_Stage|epimastigote_stage]]
+
******[[Amastigote_Stage|amastigote_stage]]
−
*****[[Gametocyte_Stage|gametocyte_stage]]
+
******[[Cercaria_Stage|cercaria_stage]]
−
******[[Macrogametocyte_Stage|macrogametocyte_stage]]
+
*******[[Schistosoma_Haematobium_Cercaria_Stage|schistosoma_haematobium_cercaria_stage]]
−
******[[Microgametocyte_Stage|microgametocyte_stage]]
+
*******[[Schistosoma_Japonicum_Cercaria_Stage|schistosoma_japonicum_cercaria_stage]]
−
*******[[Exflagellated_Microgametocyte_Stage|exflagellated_microgametocyte_stage]]
+
*******[[Schistosoma_Mansoni_Cercaria_Stage|schistosoma_mansoni_cercaria_stage]]
−
*****[[Hypnozoite_Stage|hypnozoite_stage]]
+
******[[Egg_Stage|egg_stage]]
−
*****[[Macrogamete_Stage|macrogamete_stage]]
+
*******[[Schistosoma_Haematobium_Egg_Stage|schistosoma_haematobium_egg_stage]]
−
*****[[Merozoite_Stage|merozoite_stage]]
+
*******[[Schistosoma_Japonicum_Egg_Stage|schistosoma_japonicum_egg_stage]]
−
*****[[Microgamete_Stage|microgamete_stage]]
+
*******[[Schistosoma_Mansoni_Egg_Stage|schistosoma_mansoni_egg_stage]]
−
*****[[Oocyst_Stage|oocyst_stage]]
+
******[[Epimastigote_Stage|epimastigote_stage]]
−
*****[[Ookinete_Stage|ookinete_stage]]
+
******[[Gametocyte_Stage|gametocyte_stage]]
 +
*******[[Macrogametocyte_Stage|macrogametocyte_stage]]
 +
*******[[Microgametocyte_Stage|microgametocyte_stage]]
 +
********[[Exflagellated_Microgametocyte_Stage|exflagellated_microgametocyte_stage]]
 +
******[[Hypnozoite_Stage|hypnozoite_stage]]
 +
******[[Macrogamete_Stage|macrogamete_stage]]
 +
******[[Merozoite_Stage|merozoite_stage]]
 +
******[[Microgamete_Stage|microgamete_stage]]
 +
******[[Miracidium_Stage|miracidium_stage]]
 +
*******[[Schistosoma_Haematobium_Miracidium_Stage|schistosoma_haematobium_miracidium_stage]]
 +
*******[[Schistosoma_Japonicum_Miracidium_Stage|schistosoma_japonicum_miracidium_stage]]
 +
*******[[Schistosoma_Mansoni_Miracidium_Stage|schistosoma_mansoni_miracidium_stage]]
 +
******[[Oocyst_Stage|oocyst_stage]]
 +
******[[Ookinete_Stage|ookinete_stage]]
 +
******[[Promastigote_Stage|promastigote_stage]]
 +
******[[Schistososomulum_Stage|schistosomulum_stage]]
 +
******[[Schizont_Stage|schizont_stage]]
 +
*******[[Plasmodium_Falciparum_Schizont_Stage|plasmodium_falciparum_shcizont_stage]]
 +
********[[Plasmodium_Falciparum_Erythrocytic_Schizont_Stage|plasmodium_falciparum_erythrocytic_shizont_stage]]
 +
********[[Plasmodium_Falciparum_Hepatic_Schizont_Stage|plasmodium_falciparum_hepatic_shizont_stage]]
 +
*******[[Erythrocytic_Shizont_Stage|erythrocytic_shizont_stage]]
 +
********[[Plasmodium_Falciparum_Erythrocytic_Shizont_Stage|plasmodium_falciparum_erythrocytic_shizont_stage]]
 +
*******[[Hepatic_Shizont_Stage|hepatic_shizont_stage]]
 +
********[[Plasmodium_Falciparum_Hepatic_Shizont_Stage|plasmodium_falciparum_hepatic_shizont_stage]]
 +
******[[Sporozoite_Stage|sporozoite_stage]]
 +
******[[Trophozoite_Stage|trophozoite_stage]]
 +
*******[[Ring_Trophozoite_Stage|ring_trophozoite_stage]]
 +
******[[Trypomastigote_Stage|trypomastigote_stage]]
 +
*******[[Bloodstream_Trypomastigote_Stage|bloodstream_trypomastigote_stage]]
 +
*******[[Metacyclic_Trypomastigote_Stage|metacyclic_trypomastigote_stage]]
 +
*******[[Procyclic_Trypomastigote_Stage|procyclic_trypomastigote_stage]]
 +
******[[Worm_Stage|worm_stage]]
 +
*******[[3_Week_Worm_Stage|3_week_worm_stage]]
 +
*******[[7_Week_Worm_Stage|7_week_worm_stage]]
 +
*******[[Schistosoma_Haematobium_Worm_Stage|schistosoma_haematobium_worm_stage]]
 +
*******[[Schistosoma_Japonicum_Worm_Stage|schistosoma_japonicum_worm_stage]]
 +
*******[[Schistosoma_Mansoni_Worm_Stage|schistosoma_mansoni_worm_stage]]
 +
******[[Zygote_Stage|zygote_stage]]
 
*****[[Parasite_Lifecycle_Stage|parasite_lifecycle_stage]]
 
*****[[Parasite_Lifecycle_Stage|parasite_lifecycle_stage]]
 
******[[Leishmania_Major_Lifecycle_Stage|leishmania_major_lifecycle_stage]]
 
******[[Leishmania_Major_Lifecycle_Stage|leishmania_major_lifecycle_stage]]
Line 128: Line 237:
 
********[[Plasmodium_Falciparum_Ring_Trophozoite_Stage|plasmodium_falciparum_ring_trophozoite_stage]]
 
********[[Plasmodium_Falciparum_Ring_Trophozoite_Stage|plasmodium_falciparum_ring_trophozoite_stage]]
 
*******[[Plasmodium_Falciparum_Zygote_Stage|plasmodium_falciparum_zygote_stage]]
 
*******[[Plasmodium_Falciparum_Zygote_Stage|plasmodium_falciparum_zygote_stage]]
 +
******[[Schistosoma_Haematobium_Lifecycle_Stage|schistosoma_haematobium_lifecycle_stage]]
 +
*******[[Schistosoma_Haematobium_Cercaria_Stage|schistosoma_haematobium_cercaria_stage]]
 +
*******[[Schistosoma_Haematobium_Egg_Stage|schistosoma_haematobium_egg_stage]]
 +
*******[[Schistosoma_Haematobium_Miracidium_Stage|schistosoma_haematobium_miracidium_stage]]
 +
*******[[Schistosoma_Haematobium_Schistosomulum_Stage|schistosoma_haematobium_schistosomulum_stage]]
 +
********[[Schistosoma_Haematobium_24_Hour_Schistosomulum_Stage|schistosoma_haematobium_24_hour_schistosomulum_stage]]
 +
********[[Schistosoma_Haematobium_3_Day_Schistosomulum_Stage|schistosoma_haematobium_3_day_schistosomulum_stage]]
 +
********[[Schistosoma_Haematobium_3_Hour_Schistosomulum_Stage|schistosoma_haematobium_3_hour_schistosomulum_stage]]
 +
********[[Schistosoma_Haematobium_6_Day_Schistosomulum_Stage|schistosoma_haematobium_6_day_schistosomulum_stage]]
 +
*******[[Schistosoma_Haematobium_Worm_Stage|schistosoma_haematobium_worm_stage]]
 +
********[[Schistosoma_Haematobium_3_Week_Worm_Stage|schistosoma_haematobium_3_week_worm_stage]]
 +
********[[Schistosoma_Haematobium_7_Week_Worm_Stage|schistosoma_haematobium_7_week_worm_stage]]
 +
******[[Schistosoma_Japonicum_Lifecycle_Stage|schistosoma_japonicum_lifecycle_stage]]
 +
********[[Schistosoma_Japonicum_24_Hour_Schistosomulum_Stage|schistosoma_japonicum_24_hour_schistosomulum_stage]]
 +
********[[Schistosoma_Japonicum_3_Day_Schistosomulum_Stage|schistosoma_japonicum_3_day_schistosomulum_stage]]
 +
********[[Schistosoma_Japonicum_3_Hour_Schistosomulum_Stage|schistosoma_japonicum_3_hour_schistosomulum_stage]]
 +
********[[Schistosoma_Japonicum_6_Day_Schistosomulum_Stage|schistosoma_japonicum_6_day_schistosomulum_stage]]
 +
*******[[Schistosoma_Japonicum_Worm_Stage|schistosoma_japonicum_worm_stage]]
 +
********[[Schistosoma_Japonicum_3_Week_Worm_Stage|schistosoma_japonicum_3_week_worm_stage]]
 +
********[[Schistosoma_Japonicum_7_Week_Worm_Stage|schistosoma_japonicum_7_week_worm_stage]]
 +
******[[Schistosoma_Mansoni_Lifecycle_Stage|schistosoma_mansoni_lifecycle_stage]]
 +
********[[Schistosoma_Mansoni_24_Hour_Schistosomulum_Stage|schistosoma_mansoni_24_hour_schistosomulum_stage]]
 +
********[[Schistosoma_Mansoni_3_Day_Schistosomulum_Stage|schistosoma_mansoni_3_day_schistosomulum_stage]]
 +
********[[Schistosoma_Mansoni_3_Hour_Schistosomulum_Stage|schistosoma_mansoni_3_hour_schistosomulum_stage]]
 +
********[[Schistosoma_Mansoni_6_Day_Schistosomulum_Stage|schistosoma_mansoni_6_day_schistosomulum_stage]]
 +
*******[[Schistosoma_Mansoni_Worm_Stage|schistosoma_mansoni_worm_stage]]
 +
********[[Schistosoma_Mansoni_3_Week_Worm_Stage|schistosoma_mansoni_3_week_worm_stage]]
 +
********[[Schistosoma_Mansoni_7_Week_Worm_Stage|schistosoma_mansoni_7_week_worm_stage]]
 
******[[Trypanosoma_Brucei_Lifecycle_Stage|trypanosoma_brucei_lifecycle_stage]]
 
******[[Trypanosoma_Brucei_Lifecycle_Stage|trypanosoma_brucei_lifecycle_stage]]
 
*******[[Trypanosoma_Brucei_Epimastigote_Stage|trypanosoma_brucei_epimastigote_stage]]
 
*******[[Trypanosoma_Brucei_Epimastigote_Stage|trypanosoma_brucei_epimastigote_stage]]
Line 139: Line 276:
 
*******[[Trypanosoma_Cruzi_Trypomastigote_Stage|trypanosoma_cruzi_trypomastigote_stage]]
 
*******[[Trypanosoma_Cruzi_Trypomastigote_Stage|trypanosoma_cruzi_trypomastigote_stage]]
 
********[[Trypanosoma_Cruzi_Metacyclic_Trypomastigote_Stage|trypanosoma_cruzi_metacyclic_trypomastigote_stage]]
 
********[[Trypanosoma_Cruzi_Metacyclic_Trypomastigote_Stage|trypanosoma_cruzi_metacyclic_trypomastigote_stage]]
−
*****[[Promastigote_Stage|promastigote_stage]]
 
−
*****[[Schistosomulum_Stage|schistosomulum_stage]]
 
−
*****[[Schizont_Stage|schizont_stage]]
 
−
*****[[Sporozoite_Stage|sporozoite_stage]]
 
−
*****[[Trophozoite_Stage|trophozoite_stage]]
 
−
*****[[Trypomastigote_Stage|trypomastigote_stage]]
 
−
*****[[Zygote_Stage|zygote_stage]]
 
 
}}
 
}}
  
Line 162: Line 292:
 
     <tr valign="top">
 
     <tr valign="top">
 
         <td>
 
         <td>
 +
 +
;#
 +
                              <ul>
 +
[[3_Week_Worm_Stage|
 +
[[7_Week_Worm_Stage|
 +
                              </ul>
 
;A
 
;A
 
                               <ul>
 
                               <ul>
Line 173: Line 309:
 
;B
 
;B
 
                               <ul>
 
                               <ul>
 +
[[Biological_Vector_of_Infections_Agent_Role|
 
<li>[[Biomphalaria]]</li>
 
<li>[[Biomphalaria]]</li>
 +
[[Biompharlaria_Hepatopancreas|
 
<li>[[Blood]]</li>
 
<li>[[Blood]]</li>
 +
[[Bloodstream_Trypomastigote_Stage|
 
<li>[[Bulinus]]</li>
 
<li>[[Bulinus]]</li>
 +
[[Bulinus_Hepatopancreas|
 
                               </ul>
 
                               </ul>
  
Line 182: Line 322:
 
<li>[[Canis Familiaris]]</li>
 
<li>[[Canis Familiaris]]</li>
 
<li>[[Cell]]</li>
 
<li>[[Cell]]</li>
 +
[[Cercaria_Stage|
 
<li>[[Cerebrospinal Fluid]]</li>
 
<li>[[Cerebrospinal Fluid]]</li>
 
<li>[[Continuant]]</li>
 
<li>[[Continuant]]</li>
 
                               </ul>
 
                               </ul>
 +
;D
 +
                              <ul>
 +
[[Definitive_Host_Role|
 +
[[Dependent_Contininuant|
 +
                              </ul>                         
 
                                
 
                                
 
;E
 
;E
 
                               <ul>
 
                               <ul>
 +
[[Egg_Stage|egg_stage]]
 
<li>[[Entity]]</li>
 
<li>[[Entity]]</li>
 
<li>[[Epimastigote Stage]]</li>
 
<li>[[Epimastigote Stage]]</li>
 
<li>[[Erythrocyte]]</li>
 
<li>[[Erythrocyte]]</li>
 +
[[Erythrocytic_Shizont_Stage|
 
<li>[[Exflagellated Microgametocyte Stage]]</li>
 
<li>[[Exflagellated Microgametocyte Stage]]</li>
 
                               </ul>
 
                               </ul>
Line 205: Line 353:
 
;H
 
;H
 
                               <ul>
 
                               <ul>
 +
[[Hepatic_Shizont_Stage|
 
<li>[[Hepatocyte]]</li>
 
<li>[[Hepatocyte]]</li>
 +
[[Hepatopancreas|
 
<li>[[Hindgut]]</li>
 
<li>[[Hindgut]]</li>
 
<li>[[Homo Sapiens]]</li>
 
<li>[[Homo Sapiens]]</li>
 +
[[Host_Role|
 
<li>[[Human Blood]]</li>
 
<li>[[Human Blood]]</li>
 +
[[Human_Bladder|
 
<li>[[Human Cerebrospinal Fluid]]</li>
 
<li>[[Human Cerebrospinal Fluid]]</li>
 
<li>[[Human Erythrocyte]]</li>
 
<li>[[Human Erythrocyte]]</li>
 
<li>[[Human Hepatocyte]]</li>
 
<li>[[Human Hepatocyte]]</li>
 +
[[Human_Intestine|
 +
[[Human_Liver|
 +
[[Human_Lung|
 
<li>[[Human Macrophage]]</li>
 
<li>[[Human Macrophage]]</li>
 +
[[Human_Mesenteric_Vein|
 +
[[Human_Parasite_Role|
 +
[[Human_Skin|
 +
[[Human_Ureter|
 
<li>[[Hypnozoite Stage]]</li>
 
<li>[[Hypnozoite Stage]]</li>
 
                               </ul>
 
                               </ul>
Line 219: Line 378:
 
                               <ul>
 
                               <ul>
 
<li>[[Independent Continuant]]</li>
 
<li>[[Independent Continuant]]</li>
 +
[[Infectious_Agent_Vector_Role|
 
<li>[[Insect]]</li>
 
<li>[[Insect]]</li>
 +
[[Intermediate_Host_Role|
 +
[[Intestine|
 
                               </ul>
 
                               </ul>
 
                                
 
                                
Line 233: Line 395:
 
<li>[[Leishmania Major Promastigote]]</li>
 
<li>[[Leishmania Major Promastigote]]</li>
 
<li>[[Leishmania Major Promastigote Stage]]</li>
 
<li>[[Leishmania Major Promastigote Stage]]</li>
 +
[[Lifecycle_Stage|
 +
[[Liver|
 +
[[Lung|
 
                               </ul>
 
                               </ul>
  
Line 241: Line 406:
 
<li>[[Macrophage]]</li>
 
<li>[[Macrophage]]</li>
 
<li>[[Mammal]]</li>
 
<li>[[Mammal]]</li>
 +
[[Material_Entity|
 
<li>[[Merozoite Stage]]</li>
 
<li>[[Merozoite Stage]]</li>
 +
[[Mesenteric_Vein|
 +
[[Metacyclic_Trypomastigote_Stage|
 
<li>[[Microgamete Stage]]</li>
 
<li>[[Microgamete Stage]]</li>
 
<li>[[Microgametocyte Stage]]</li>
 
<li>[[Microgametocyte Stage]]</li>
 
<li>[[Midgut]]</li>
 
<li>[[Midgut]]</li>
 +
[[Miracidium_Stage|
 
<li>[[Mollusca]]</li>
 
<li>[[Mollusca]]</li>
 
<li>[[Mus Musculus]]</li>
 
<li>[[Mus Musculus]]</li>
Line 255: Line 424:
 
<li>[[Occurrent]]</li>
 
<li>[[Occurrent]]</li>
 
<li>[[Oncomelania]]</li>
 
<li>[[Oncomelania]]</li>
 +
[[Oncomelania_Hepatopancreas|
 
<li>[[Oocyst Stage]]</li>
 
<li>[[Oocyst Stage]]</li>
 
<li>[[Ookinete Stage]]</li>
 
<li>[[Ookinete Stage]]</li>
Line 263: Line 433:
 
                               <ul>
 
                               <ul>
 
<li>[[Parasite Lifecycle Stage]]</li>
 
<li>[[Parasite Lifecycle Stage]]</li>
 +
[[Parasite_Role|
 
<li>[[Parasite Organism]]</li>
 
<li>[[Parasite Organism]]</li>
 
<li>[[Phlebotominae]]</li>
 
<li>[[Phlebotominae]]</li>
Line 300: Line 471:
 
<li>[[Proboscis]]</li>
 
<li>[[Proboscis]]</li>
 
<li>[[Processual Entity]]</li>
 
<li>[[Processual Entity]]</li>
 +
[[Procyclic_Trypomastigote_Stage|
 
<li>[[Promastigote Stage]]</li>
 
<li>[[Promastigote Stage]]</li>
 
                               </ul>
 
                               </ul>
Line 306: Line 478:
  
 
<td>
 
<td>
 +
;R
 +
<ul>
 +
[[Realizable_Entity|
 +
[[Ring_Trophozoite_Stage|
 +
[[Role|
 +
</ul>
 
;S
 
;S
 
                               <ul>
 
                               <ul>
Line 311: Line 489:
 
<li>[[Schistosoma]]</li>
 
<li>[[Schistosoma]]</li>
 
<li>[[Schistosoma Haematobium]]</li>
 
<li>[[Schistosoma Haematobium]]</li>
 +
[[Schistosoma_Haematobium_24_Hour_Schistosomulum|
 +
[[Schistosoma_Haematobium_24_Hour_Schistosomulum_Stage|
 +
[[Schistosoma_Haematobium_3_Day_Schistosomulum|
 +
[[Schistosoma_Haematobium_3_Day_Schistosomulum_Stage|
 +
[[Schistosoma_Haematobium_3_Hour_Schistosomulum|
 +
[[Schistosoma_Haematobium_3_Hour_Schistosomulum_Stage|
 +
[[Schistosoma_Haematobium_3_Week_Worm|
 +
[[Schistosoma_Haematobium_3_Week_Worm_Stage|
 +
[[Schistosoma_Haematobium_6_Day_Schistosomulum|
 +
[[Schistosoma_Haematobium_6_Day_Schistosomulum_Stage|
 +
[[Schistosoma_Haematobium_7_Week_Worm|
 +
[[Schistosoma_Haematobium_7_Week_Worm_Stage|
 +
[[Schistosoma_Haematobium_Cercaria|
 +
[[Schistosoma_Haematobium_Cercaria_Stage|
 +
[[Schistosoma_Haematobium_Daughter_Sporocyst|
 +
[[Schistosoma_Haematobium_Egg|
 +
[[Schistosoma_Haematobium_Egg_Stage|
 +
[[Schistosoma_Haematobium_Lifecycle_Stage|
 +
[[Schistosoma_Haematobium_Miracidium|
 +
[[Schistosoma_Haematobium_Miracidium_Stage|
 +
[[Schistosoma_Haematobium_Mother_Sporocyst|
 +
[[Schistosoma_Haematobium_Schistosomulum|
 +
[[Schistosoma_Haematobium_Schistosomulum_Stage|
 +
[[Schistosoma_Haematobium_Sporocyst|
 +
[[Schistosoma_Haematobium_Worm|
 +
[[Schistosoma_Haematobium_Worm_Stage|
 
<li>[[Schistosoma Japonicum]]</li>
 
<li>[[Schistosoma Japonicum]]</li>
 +
[[Schistosoma_Japonicum_24_Hour_Schistosomulum|
 +
[[Schistosoma_Japonicum_24_Hour_Schistosomulum_Stage|s
 +
[[Schistosoma_Japonicum_3_Day_Schistosomulum|
 +
[[Schistosoma_Japonicum_3_Day_Schistosomulum_Stage|
 +
[[Schistosoma_Japonicum_3_Hour_Schistosomulum|
 +
[[Schistosoma_Japonicum_3_Hour_Schistosomulum_Stage|
 +
[[Schistosoma_Japonicum_3_Week_Worm|
 +
[[Schistosoma_Japonicum_3_Week_Worm_Stage|
 +
[[Schistosoma_Japonicum_6_Day_Schistosomulum|
 +
[[Schistosoma_Japonicum_6_Day_Schistosomulum_Stage|
 +
[[Schistosoma_Japonicum_7_Week_Worm|
 +
[[Schistosoma_Japonicum_7_Week_Worm_Stage|
 +
[[Schistosoma_Japonicum_Cercaria|
 +
[[Schistosoma_Japonicum_Cercaria_Stage|
 +
[[Schistosoma_Japonicum_Daughter_Sporocyst|
 +
[[Schistosoma_Japonicum_Egg|
 +
[[Schistosoma_Japonicum_Egg_Stage|
 +
[[Schistosoma_Japonicum_Lifecycle_Stage|
 +
[[Schistosoma_Japonicum_Miracidium|
 +
[[Schistosoma_Japonicum_Miracidium_Stage|
 +
[[Schistosoma_Japonicum_Mother_Sporocyst|
 +
[[Schistosoma_Japonicum_Schistosomulum|
 +
[[Schistosoma_Japonicum_Sporocyst|
 +
[[Schistosoma_Japonicum_Worm|
 +
[[Schistosoma_Japonicum_Worm_Stage|
 
<li>[[Schistosoma Mansoni]]</li>
 
<li>[[Schistosoma Mansoni]]</li>
 +
[[Schostosoma_Mansoni_24_Hour_Schistosomulum|
 +
[[Schistosoma_Mansoni_24_Hour_Schistosomulum_Stage|
 +
[[Schostosoma_Mansoni_3_Day_Schistosomulum|
 +
[[Schistosoma_Mansoni_3_Day_Schistosomulum_Stage|
 +
[[Schostosoma_Mansoni_3_Hour_Schistosomulum|
 +
[[Schistosoma_Mansoni_3_Hour_Schistosomulum_Stage|
 +
[[Schostosoma_Mansoni_3_Week_Worm|
 +
[[Schistosoma_Mansoni_3_Week_Worm_Stage|
 +
[[Schostosoma_Mansoni_6_Day_Schistosomulum|
 +
[[Schistosoma_Mansoni_6_Day_Schistosomulum_Stage|
 +
[[Schostosoma_Mansoni_7_Week_Worm|
 +
[[Schistosoma_Mansoni_7_Week_Worm_Stage|
 +
[[Schostosoma_Mansoni_Cercaria|
 +
[[Schistosoma_Mansoni_Cercaria_Stage|
 +
[[Schistosoma_Mansoni_Daughter_Sporocyst|
 +
[[Schostosoma_Mansoni_Egg|
 +
[[Schistosoma_Mansoni_Egg_Stage|
 +
[[Schistosoma_Mansoni_Lifecycle_Stage|
 +
[[Schostosoma_Mansoni_Miracidium|
 +
[[Schistosoma_Mansoni_Miracidium_Stage|
 +
[[Schistosoma_Mansoni_Mother_Sporocyst|
 +
[[Schostosoma_Mansoni_Schistosomulum|
 +
[[Schistosoma_Mansoni_Sporocyst|
 +
[[Schistosoma_Mansoni_Worm_Stage|
 
<li>[[Schistosomulum Stage]]</li>
 
<li>[[Schistosomulum Stage]]</li>
 
<li>[[Schizont Stage]]</li>
 
<li>[[Schizont Stage]]</li>
 +
[[Skin_Of_Body|
 +
[[Specifically_Dependent_Continuant|
 
<li>[[Sporozoite Stage]]</li>
 
<li>[[Sporozoite Stage]]</li>
 
                               </ul>
 
                               </ul>
Line 341: Line 596:
 
<li>[[Trypomastigote Stage]]</li>
 
<li>[[Trypomastigote Stage]]</li>
 
                               </ul>
 
                               </ul>
 +
;U
 +
<ul>
 +
[[Urinary_Bladder|
 +
[[Ureter|
 +
</ul>
  
 
;V
 
;V
 
                               <ul>
 
                               <ul>
 
<li>[[Vertebrate]]</li>
 
<li>[[Vertebrate]]</li>
 +
                              </ul>
 +
;W
 +
                              <ul>
 +
[[Worm_Stage|
 
                               </ul>
 
                               </ul>
  

Revision as of 21:08, 28 January 2011


What is Parasite Lifecycle Ontology (PLO)?

PLO models the life cycle stage details of T.cruzi and two related kinetoplastids, Trypanosoma brucei and Leishmania major. In addition, the ontology also models necessary contextual details such as host information, vector information, strain and anatomical location. All the entities in the ontology are linked to each other by explicitly modeled named relationships that will enable software applications to accurately interpret data annotated with this ontology. For example, “Trypanosoma_cruzi→has_vector_organism→triatominae”. The PLO is modeled in the W3C Web Ontology Language (OWL) standard and currently has 41 classes and 5 properties with a description logic expressivity of ALU. PLO (ver 0.1) is released through NCBO’s BioPortal repository for public use.

Snapshot of class hierarchy of the parasite life cycle ontology using Protege toolkit. Detail of this ontology is available at NCBO BioPortal

{{block 

 |title= List of ontology classes
 |title_background=#b0e2ff
 |content=
    [[3_Week_Worm_Stage| [[7_Week_Worm_Stage|
A
B
    [[Biological_Vector_of_Infections_Agent_Role|
  • Biomphalaria

    • [[Biompharlaria_Hepatopancreas|

  • Blood

    • [[Bloodstream_Trypomastigote_Stage|

  • Bulinus

    • [[Bulinus_Hepatopancreas|

C
D
    [[Definitive_Host_Role| [[Dependent_Contininuant|
E
G
H
I
L
M
O


P
R
    [[Realizable_Entity| [[Ring_Trophozoite_Stage| [[Role|
S
  • Salivary Gland
  • Schistosoma
  • Schistosoma Haematobium

    • [[Schistosoma_Haematobium_24_Hour_Schistosomulum| [[Schistosoma_Haematobium_24_Hour_Schistosomulum_Stage| [[Schistosoma_Haematobium_3_Day_Schistosomulum| [[Schistosoma_Haematobium_3_Day_Schistosomulum_Stage| [[Schistosoma_Haematobium_3_Hour_Schistosomulum| [[Schistosoma_Haematobium_3_Hour_Schistosomulum_Stage| [[Schistosoma_Haematobium_3_Week_Worm| [[Schistosoma_Haematobium_3_Week_Worm_Stage| [[Schistosoma_Haematobium_6_Day_Schistosomulum| [[Schistosoma_Haematobium_6_Day_Schistosomulum_Stage| [[Schistosoma_Haematobium_7_Week_Worm| [[Schistosoma_Haematobium_7_Week_Worm_Stage| [[Schistosoma_Haematobium_Cercaria| [[Schistosoma_Haematobium_Cercaria_Stage| [[Schistosoma_Haematobium_Daughter_Sporocyst| [[Schistosoma_Haematobium_Egg| [[Schistosoma_Haematobium_Egg_Stage| [[Schistosoma_Haematobium_Lifecycle_Stage| [[Schistosoma_Haematobium_Miracidium| [[Schistosoma_Haematobium_Miracidium_Stage| [[Schistosoma_Haematobium_Mother_Sporocyst| [[Schistosoma_Haematobium_Schistosomulum| [[Schistosoma_Haematobium_Schistosomulum_Stage| [[Schistosoma_Haematobium_Sporocyst| [[Schistosoma_Haematobium_Worm| [[Schistosoma_Haematobium_Worm_Stage|

  • Schistosoma Japonicum

    • [[Schistosoma_Japonicum_24_Hour_Schistosomulum| [[Schistosoma_Japonicum_24_Hour_Schistosomulum_Stage|s [[Schistosoma_Japonicum_3_Day_Schistosomulum| [[Schistosoma_Japonicum_3_Day_Schistosomulum_Stage| [[Schistosoma_Japonicum_3_Hour_Schistosomulum| [[Schistosoma_Japonicum_3_Hour_Schistosomulum_Stage| [[Schistosoma_Japonicum_3_Week_Worm| [[Schistosoma_Japonicum_3_Week_Worm_Stage| [[Schistosoma_Japonicum_6_Day_Schistosomulum| [[Schistosoma_Japonicum_6_Day_Schistosomulum_Stage| [[Schistosoma_Japonicum_7_Week_Worm| [[Schistosoma_Japonicum_7_Week_Worm_Stage| [[Schistosoma_Japonicum_Cercaria| [[Schistosoma_Japonicum_Cercaria_Stage| [[Schistosoma_Japonicum_Daughter_Sporocyst| [[Schistosoma_Japonicum_Egg| [[Schistosoma_Japonicum_Egg_Stage| [[Schistosoma_Japonicum_Lifecycle_Stage| [[Schistosoma_Japonicum_Miracidium| [[Schistosoma_Japonicum_Miracidium_Stage| [[Schistosoma_Japonicum_Mother_Sporocyst| [[Schistosoma_Japonicum_Schistosomulum| [[Schistosoma_Japonicum_Sporocyst| [[Schistosoma_Japonicum_Worm| [[Schistosoma_Japonicum_Worm_Stage|

  • Schistosoma Mansoni

    • [[Schostosoma_Mansoni_24_Hour_Schistosomulum| [[Schistosoma_Mansoni_24_Hour_Schistosomulum_Stage| [[Schostosoma_Mansoni_3_Day_Schistosomulum| [[Schistosoma_Mansoni_3_Day_Schistosomulum_Stage| [[Schostosoma_Mansoni_3_Hour_Schistosomulum| [[Schistosoma_Mansoni_3_Hour_Schistosomulum_Stage| [[Schostosoma_Mansoni_3_Week_Worm| [[Schistosoma_Mansoni_3_Week_Worm_Stage| [[Schostosoma_Mansoni_6_Day_Schistosomulum| [[Schistosoma_Mansoni_6_Day_Schistosomulum_Stage| [[Schostosoma_Mansoni_7_Week_Worm| [[Schistosoma_Mansoni_7_Week_Worm_Stage| [[Schostosoma_Mansoni_Cercaria| [[Schistosoma_Mansoni_Cercaria_Stage| [[Schistosoma_Mansoni_Daughter_Sporocyst| [[Schostosoma_Mansoni_Egg| [[Schistosoma_Mansoni_Egg_Stage| [[Schistosoma_Mansoni_Lifecycle_Stage| [[Schostosoma_Mansoni_Miracidium| [[Schistosoma_Mansoni_Miracidium_Stage| [[Schistosoma_Mansoni_Mother_Sporocyst| [[Schostosoma_Mansoni_Schistosomulum| [[Schistosoma_Mansoni_Sporocyst| [[Schistosoma_Mansoni_Worm_Stage|

  • Schistosomulum Stage
  • Schizont Stage

    • [[Skin_Of_Body| [[Specifically_Dependent_Continuant|

  • Sporozoite Stage
T
U
    [[Urinary_Bladder| [[Ureter|
V
W
    [[Worm_Stage|
Z

}}


Organisms in PLO

Here is brief description and life-cycles of the organisms that are covered in PLO.

Trypanosoma cruzi
T. cruzi Lifecycle

The life cycle of Trypanosoma cruzi involves both vertebrate and invertebrate hosts (see figure below). Metacyclic trypomastigotes are deposited on the mammalian (vertebrate host's) skin through the faeces of the triatomine bug vector. They have the capacity to penetrate skin through wounds, such as the bite from the bug, and across the mucosal membranes surrounding the eyes and mouth.

Inside the mammalian host, the trypomastigotes penetrate either phagocytic or non-phagocytic cells, in a manner distinct from phagocytosis. Parasites subvert the host cell Ca2+ -regulated lysosomal exocytic pathway, literally ‘hijacking’ lysosomes to enable them to invade effectively (Sibley and Andrews, 2000; Tan and Andrews, 2002). Within the host cell, trypomastigotes are initially held within a membrane bound vacuole. They subsequently enter the host cell cytoplasm directly, transforming into amastigotes (the intracellular replicative forms) (Tan and Andrews, 2002). Around five days post invasion, the amastigotes transform back into C- shaped trypomastigotes, and the host cell ruptures, releasing the parasites into the bloodstream. These bloodstream trypomastigotes can then either infect further cells, or can be taken up by a reduviid bug. Within the insect vector, epimastigotes develop in the alimentary tract, taking 10 – 15 days to replicate and transform into infective stages in the rectum (Kollien and Schaub, 2000). T. cruzi can also be transmitted via contaminated blood and infected organs used in transplant operations, or congenitally from mother to child.

Trypanosoma brucei
T. brucei Lifecyle

Trypanosoma brucei is also transmitted by an insect vector, in this case the tsetse fly, one of the Glossina sp. Blood stream trypomastigotes are ingested by the tsetse from an infected patient during the insect blood meal. In the midgut of the tsetse, the trypanosomes develop into procyclic forms that divide by binary fission. Some of these then migrate to the salivary glands where they differentiate into infectious metacyclic trypomastigotes. These are transmitted into new hosts during further blood feeds (Barrett et al, 2003).

Leishmania sp.
Leishmania sp. Lifecycle

Leishmania species are also transmitted by insect vectors, in this case metacyclic promastigotes are introduced into the skin by the bite of various species of sand fly. These are taken up by macrophages and transform into intracellular amastigotes (reviewed by Handman and Bullen, 2002), remaining in this form for the duration of the life cycle in the mammalian host. Development within the sand fly vector varies from species to species, but is thought to involve 2 distinct growth phases (Gossage et al, 2003).

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